JARED CUMMINGS : rechercher sur Z-Library

Gary H. Posner, Xueliang Tao, Jared N. Cumming, Donna Klinedinst, Theresa A. Shapiro

Année:

1996

Langue:

english

Fichier:

PDF, 232 KB

english, 1996

Antimalarially potent, easily prepared, fluorinated endoperoxides

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 219 KB

english, 1996

Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization

Jared Cumming, Suresh Babu, Ying Huang, Carolyn Carrol, Xia Chen, Leonard Favreau, William Greenlee, Tao Guo, Matthew Kennedy, Reshma Kuvelkar, Thuy Le, Guoqing Li, Nansie McHugh, Peter Orth, Lynne Oz

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 2.34 MB

english, 2010

Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides

Gary H. Posner, Lluïsa González, Jared N. Cumming, Donna Klinedinst, Theresa A. Shapiro

Journal:

Tetrahedron

Année:

1997

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1997

Stereoselective synthesis of 7R-paeonimetaboline-I; Stereoselective route towards paeoniflorigenone

David P. Richardson, Priscilla W. Carr, Jared N. Cumming, Warren G. Harbison, Nina D. Raoof, Michelle S. Sanders, Eliza Shin, Thomas E. Smith, Thomas H. Wintner

Journal:

Bioorganic & Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 216 KB

english, 1997

Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro

Gary H. Posner, Poonsakdi Ploypradith, Whitney Hapangama, Dasong Wang, Jared N. Cumming, Patrick Dolan, Thomas W. Kensler, Donna Klinedinst, Theresa A. Shapiro, Qun Yi Zheng, Christopher K. Murray, Ly

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 940 KB

english, 1997

Antimalarial sulfone trioxanes

Gary H. Posner, Hardwin O'Dowd, Thomas Caferro, Jared N. Cumming, Poonsakdi Ploypradith, Suji Xie, Theresa A. Shapiro

Journal:

DELBERT W. HUTCHISON, JARED L. STRASBURG, JENNIFER A. BRISSON, SHAWN CUMMINGS

Année:

1998

Langue:

english

Fichier:

PDF, 327 KB

english, 1998

Isolation and characterization of 11 polymorphic microsatellite loci in collared lizards (Crotaphytus collaris)

Journal:

Molecular Ecology Resources

Année:

2004

Langue:

english

Fichier:

PDF, 73 KB

english, 2004

ChemInform Abstract: Structure Based Design of Iminohydantoin BACE1 Inhibitors: Identification of an Orally Available, Centrally Active BACE1 Inhibitor (I).

Jared N. Cumming, et al. et al.

Journal:

ChemInform

Année:

2012

Fichier:

PDF, 21 KB

2012

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang, Jeffrey Misiaszek, James Durkin, Jianping Pan, Ulrich Iserloh, Yusheng Wu, Zhaoning Zhu, Corey Strickland, Johannes Voigt, Xia Chen, Matthew E. Kenn

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 717 KB

english, 2012

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N., Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D., Caldwell, John P., Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giu

Journal:

Posner, Gary H., Wang, Dasong, Cumming, Jared N., Oh, Chang Ho, French, Andrew N., Bodley, Annette L., Shapiro, Theresa A.

Année:

2012

Langue:

english

Fichier:

PDF, 678 KB

english, 2012

Further Evidence Supporting the Importance of and the Restrictions on a Carbon-Centered Radical for High Antimalarial Activity of 1,2,4-Trioxanes Like Artemisinin

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 301 KB

english, 1995

Effect of a novel BACE inhibitor in the cisterna magna ported conscious rhesus monkey model

Maria Michener, Guoxin Wu, Matthew Kennedy, Jared Cumming, Mandy Dancho, Rachel Korn, Christina Lennox, Izabela Suchecki, David Gilberto, James Hershey, Debra McLoughlin, Zhong-Yue Sun, Zhaoning Zhu,

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 93 KB

english, 2012

Chronic BACE inhibition halts further age-related increases in brain Aß and amyloid plaques in aged TgCRND8 mice with established plaques

Lynn Hyde, Cinzia Cantu, Bonnie Werner, Xia Chen, Marie Sondey, Maxine Chen, Blair Weig, Abigail LaShomb, Sherry Lu, Robert Hodgson, Jack Scott, Jared Cumming, Andrew Stamford, Eric Parker, Matthew Ke

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 61 KB

english, 2012

Chronic BACE inhibition dramatically slows the rate of Aß accumulation and the development of amyloid plaques in young TgCRND8 mice

Lynn Hyde, Xia Chen, Lindsay Stahl, Marie Sondey, Jack Scott, Jared Cumming, Andrew Stamford, Eric Parker, Matthew Kennedy

Journal:

Annette L. Bodley, Jared N. Cumming, Theresa A. Shapiro

Année:

2012

Langue:

english

Fichier:

PDF, 60 KB

english, 2012

Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

Journal:

Biochemical Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 383 KB

english, 1998

Design, Synthesis, Derivatization, and Structure−Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial Artemisinin

Cumming, Jared N., Wang, Dasong, Park, Sheldon B., Shapiro, Theresa A., Posner, Gary H.

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 364 KB

english, 1998

[Advances in Pharmacology] Volume 37 || Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action

Cumming, Jared N.

Année:

1996

Langue:

english

Fichier:

PDF, 2.50 MB

english, 1996

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation ∥ (1)

Zhu, Zhaoning, Sun, Zhong-Yue, Ye, Yuanzan, Voigt, Johannes, Strickland, Corey, Smith, Elizabeth M., Cumming, Jared, Wang, Lingyan, Wong, Jesse, Wang, Yu-Sen, Wyss, Daniel F., Chen, Xia, Kuvelkar, Res

Journal:

Posner, Gary H., Cumming, Jared N., Woo, Soon-Hyung, Ploypradith, Poonsakdi, Xie, Suji, Shapiro, Theresa A.

Année:

2010

Langue:

english

Fichier:

PDF, 3.19 MB

english, 2010

Orally Active Antimalarial 3-Substituted Trioxanes: New Synthetic Methodology and Biological Evaluation

Journal:

Posner, Gary H., Cumming, Jared N., Ploypradith, Poonsakdi, Oh, Chang Ho

Année:

1998

Langue:

english

Fichier:

PDF, 277 KB

english, 1998

Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 315 KB

english, 1995

Evidence for the Importance of High-Valent FeO and of a Diketone in the Molecular Mechanism of Action of Antimalarial Trioxane Analogs of Artemisinin

Posner, Gary H., Park, Sheldon B., González, Lluïsa, Wang, Dasong, Cumming, Jared N., Klinedinst, Donna, Shapiro, Theresa A., Bachi, Mario D.

Journal:

Journal of the American Chemical Society

Année:

1996

Langue:

english

Fichier:

PDF, 136 KB

english, 1996

Improved interpretation of amyloid tracer kinetic data through model-based analysis

Stone, Julie, Kleijn, Huub Jan, Bradstreet, Thomas E., Drexel, Melissa, Savage, Mary, Forman, Mark, Spellman, Daniel, Laterza, Omar, Chappell, Derek, Chappell, Gloria, Tanen, Michael, Cumming, Jared,

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 84 KB

english, 2013

Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease

Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Cumming, Jared, Iserloh, Ulrich, McKittrick, Brian, Pan, Janping, Smith, Elizabeth, Sun, Zhong-Yue, Stamford, Andrew, Zhu, Zhaoning, Beyer, Brian, Str

Journal:

Posner, Gary H., O'Dowd, Hardwin, Ploypradith, Poonsakdi, Cumming, Jared N., Xie, Suji, Shapiro, Theresa A.

Année:

2010

Langue:

english

Fichier:

PDF, 47 KB

english, 2010

Antimalarial Cyclic Peroxy Ketals

Journal:

Ho Oh, Chang, Wang, Dasong, Cumming, Jared N., Posner, Gary H.

Année:

1998

Langue:

english

Fichier:

PDF, 78 KB

english, 1998

Antimalarial 1,2,4-Trioxanes Related to Artemisinin: Rules for Assignment of Relative Stereochemistry in Diversely Substituted Analogs

Journal:

Spectroscopy Letters

Année:

1997

Langue:

english

Fichier:

PDF, 650 KB

english, 1997

The Thermal Evolution following a Superburst on an Accreting Neutron Star

Cumming, Andrew, Macbeth, Jared

Journal:

The Astrophysical Journal

Année:

2004

Langue:

english

Fichier:

PDF, 96 KB

english, 2004

Long Type I X‐Ray Bursts and Neutron Star Interior Physics

Cumming, Andrew, Macbeth, Jared, Zand, J. J. M. in ’t, Page, Dany

Journal:

The Astrophysical Journal

Année:

2006

Langue:

english

Fichier:

PDF, 683 KB

english, 2006

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Scott, Jack D., Li, Sarah W., Brunskill, Andrew P. J., Chen, Xia, Cox, Kathleen, Cumming, Jared N., Forman, Mark, Gilbert, Eric J., Hodgson, Robert A., Hyde, Lynn A., Jiang, Qin, Iserloh, Ulrich, Kaza

Journal: